FIELD : medicine.SUBSTANCE : invention relates to medicine, namely to dentistry, and has a therapeutic and prophylactic orientation. Proposed therapeutic and preventive toothpaste contains, in wt% : 3.13–6.81?% aqueous dispersion of hydroxyapatite with a particle size of 20–80?nm (which corresponds to 1.00–2.00?wt% of dry matter) – 26.39–32.50; silicon dioxide – 5.00–10.00; 1, 2-propandiol – 3.00–5.50; 0.74–2.60?% aqueous solution of sodium carboxymethylcellulose – 25.20–31.30 (which corresponds to 0.20–0.80 wt% of dry matter); papain – 0.01–1.00; cocamidopropyl betaine – 0.10–0.20; titanium dioxide – 0.10–0.20; silicon glycerolates of Si(C3H7O3)4?6C3H8O3 composition– the rest.EFFECT : composition of the toothpaste provides a remineralizing effect, an increase in the resistance of the tooth enamel, an anti-inflammatory and wound-healing effect, as well as a positive effect on hyperesthesia and hyposalivation.1 cl, 2 dwg, 6 tbl, 8 ex