PROBLEM TO BE SOLVED : To provide a combination of Fabry disease therapeutic medicines and a use thereof. SOLUTION : A combination of Fabry disease therapeutic medicines contains a protein that has mutation in an amino acid sequence of α-N-acetylgalactosaminidase also has α-galactosidase activity, and an active site-specific chaperone. SELECTED DRAWING : Figure 1 COPYRIGHT : (C)2019, JPO&INPIT