PROBLEM TO BE SOLVED : To provide systems and methods for production of optimal combination drug products for individual patients.SOLUTION : A system 100 comprises a processor 104 and a drug substance production device 140. The processor 104 receives patient information 110 and predicts an optimal combination drug product on the basis of the patient information 110. The drug substance production device 140 includes drug substance containers, a drug substance dispenser, and a controller, and communicates with the processor 104 to produce the drug product on the basis of the predicted optimal combination drug product.SELECTED DRAWING : Figure 1COPYRIGHT : (C)2019, JPO&INPIT