FIELD : medicine.SUBSTANCE : group of inventions refers to medicine, namely to oncology, and can be used to treat malignant tumors. Methods of the invention include the preparation and introduction into the tumor of immature dendritic cells, thereafter, administration of cytotoxic T lymphocytes and/or NKT cells and anti-TNF and/or anti-IL-10 antibodies to the tumor within the tumor.EFFECT : use of inventions allows regression, reduction or elimination of tumor cells in the tumor tissue of patients.17 cl, 4 tbl, 4 dwg, 4 ex