PROBLEM TO BE SOLVED : To provide cartilage matrix-degrading enzyme production inhibitors and agents for preventing or mitigating a symptom or disease (e.g., osteoarthritis) caused by decrease of or damage to a cartilage matrix, which contain as an active ingredient a low molecular weight compound that can be relatively simply and inexpensively produced. SOLUTION : One or more compounds selected from the group consisting of compounds represented by the general formulas (I0), (II) and (III) in the figure and, when R3 is OH, pharmaceutically acceptable salts thereof are used as a cartilage matrix-degrading enzyme production inhibitor or an agent for preventing or mitigating a symptom or disease caused by decrease of or damage to a cartilage matrix. SELECTED DRAWING : None COPYRIGHT : (C)2019, JPO&INPIT