专利名称 | RECOMBINANT EL1 PEPTIDE HAVING CYTOTOXIC ACTIVITY RELATIVE TO HUMAN CANCER CELLS | ||
申请号 | RU2017142060 | 申请日 | |
公开(公告)号 | RU2683221C1 | 公开(公告)日 | |
申请(专利权)人 | Federalnoe gosudarstvennoe byudzhetnoe uchrezhdenie nauki Institut khimicheskoj biologii i fundamentalnoj meditsiny Sibirskogo otdeleniya Rossijskoj akademii nauk (IKHBFM SO RAN) (RU) | 发明人 | Koval Olga Aleksandrovna; Volkova Olga Yurevna; Gorchakov Andrej Aleksandrovich; Kulemzin Sergej Viktorovich; Tkachenko Anastasiya Viktorovna; Nushtaeva Anna Andreevna; Kuligina Elena Vladimirovna; Rikhter Vladimir Aleksandrovich; Taranin Aleksandr Vladimirovich |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
FIELD : biotechnology.SUBSTANCE : invention relates to biotechnology, specifically to the production of recombinant lactaptine analogues, and can be used in medicine. Plasmid DNA pEL1 is engineered to provide synthesis of a recombinant EL1 peptide in mammalian cells, and the recombinant EL1 peptide having a molecular weight of 14.1?kDa is obtained.EFFECT : invention provides preparing a recombinant anti-tumor EL1 peptide, having high cytotoxic activity relative to human cancer cells.1 cl, 4 dwg, 4 ex |