FIELD : medicine; pharmaceuticals.SUBSTANCE : invention relates to the pharmaceutical industry, and in particular to a method for reducing pyrogenicity of an extract of sulfated polysaccharides. Said method for reducing pyrogenicity of an extract of sulfated polysaccharides, including sulfated polysacchride and a pyrogenic agent, wherein the method includes contacting the extract with an effective amount of oxidant. Biologically active extract.EFFECT : claimed method allows to effectively reduce pyrogenicity of the sulfated polysaccharide extract.18 cl, 22 ex