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专利概况
专利名称 SALTS OF CARBAMOYL PHOSPHONIC ACID ESTERS WHICH ACT AS SELECTIVE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS HIV-1 PRODUCTION
申请号 KR1020147013013 申请日
公开(公告)号 KR101976231B1 公开(公告)日
申请(专利权)人 자크리토에 악치오네르노에 오브쉐스토보 "프로이즈보드스트벤노 콤머체스카야 아쏘치아치야 아즈트" 发明人 골루베바 나탈야 알렉산드로브나; 야스코 막심 블라디미로비치; 타루소바 나탈야 보리소브나; 비빌라쉬빌리 로베르트 샬보비치; 코노노브 알렉산데르 바실리에비치
专利来源 国家知识产权局 转化方式
摘要

The invention relates to the field of molecular biology, virology and medicine and concerns novel biologically active compounds, namely, carbamoyl phosphonate salts of the general formula given in the description. The novel compounds are able to selectively inhibit the production of human immunodeficiency virus (HIV), and can therefore be considered for use in the field of medicine for the treatment of AIDS. They are produced by adding an equimolar quantity of ammonia, a corresponding amino compound or alkali or earth-alkali metal hydroxide to an acid form of the carbamoyl phosphonate. The resultant solutions of the salts are boiled down to small volumes, from which spontaneous crystallization starts, and are left at 4癈 until the crystallization is complete. The precipitate is filtered and vacuum dried. The target compound yield is 95-98%. The novel compounds inhibit proliferation of HIV-1 in MT-4 lymphocyte cell cultures and are stable compounds, which facilitates drug creation on their basis.

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