专利名称 | T CELL RECEPTORS | ||
申请号 | EP14748262 | 申请日 | |
公开(公告)号 | EP3024468B1 | 公开(公告)日 | |
申请(专利权)人 | Adaptimmune Limited | 发明人 | MOLLOY Peter; PUMPHREY Nicholas Jonathan |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The present invention relates to T cell receptors (TCRs) which bind the HLA-A2 restricted FMNKFIYEI (158-166) peptide epitope derived from α Fetoprotein (AFP). Certain preferred TCRs of the invention demonstrate excellent binding characteristics and specificity profiles for this AFP epitope. T cell receptors of the invention comprise at least one TCR alpha chain variable domain and/or at least one TCR beta chain variable domain, the alpha chain variable domain comprising an amino acid sequence that has at least 90% identity to the sequence of amino acid residues 1- 112 of SEQ ID No : 2, and/or the beta chain variable domain comprising an amino acid sequence that has at least 90% identity to the sequence of amino acid residues 1- 112 of SEQ ID No : 3. |