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专利概况
专利名称 T CELL RECEPTORS
申请号 EP14748262 申请日
公开(公告)号 EP3024468B1 公开(公告)日
申请(专利权)人 Adaptimmune Limited 发明人 MOLLOY Peter; PUMPHREY Nicholas Jonathan
专利来源 国家知识产权局 转化方式
摘要

The present invention relates to T cell receptors (TCRs) which bind the HLA-A2 restricted FMNKFIYEI (158-166) peptide epitope derived from α Fetoprotein (AFP). Certain preferred TCRs of the invention demonstrate excellent binding characteristics and specificity profiles for this AFP epitope. T cell receptors of the invention comprise at least one TCR alpha chain variable domain and/or at least one TCR beta chain variable domain, the alpha chain variable domain comprising an amino acid sequence that has at least 90% identity to the sequence of amino acid residues 1- 112 of SEQ ID No : 2, and/or the beta chain variable domain comprising an amino acid sequence that has at least 90% identity to the sequence of amino acid residues 1- 112 of SEQ ID No : 3.

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