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专利概况
专利名称 MORPHINAN DERIVATIVE
申请号 EP17839452 申请日
公开(公告)号 EP3498711A1 公开(公告)日
申请(专利权)人 Nippon Chemiphar Co Ltd 发明人 NAGASE Hiroshi; FUJII Hideaki; SAITOH Akiyoshi; NAKATA Eriko; HIROSE Masaaki; OOI Isao; HAYASHIDA Kohei
专利来源 国家知识产权局 转化方式
摘要

A compound represented by the following general formula (I), wherein R1 represents hydrogen, C1-10 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms and the alkylene moiety has 1 to 5 carbon atoms, or the like, R2 represents a 4- to 7-membered saturated heterocycle containing one or two heteroatoms which may be the same or different and are selected from N, O, and S, and two or more carbon atoms as ring-constituting atoms, the heterocycle may be substituted with a substituent such as an oxo group, R2 binds to Y via a carbon atom as a ring-constituting atom of R2, R3, R4, and R5, which are the same or different, represent hydrogen; hydroxy; or the like, R6a and R6b, which are the same or different, represent hydrogen or the like, R7 and R8, which are the same or different, represent hydrogen or the like, R9 and R10, which are the same or different, represent hydrogen or the like, X represents O or CH2, and Y represents C(= O) or the like), a tautomer of the compound, a stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic, an antidepressant, or the like.

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