A P2X4 receptor antagonist such as paroxetine, a di- azepinedione derivative having the following formula (IX) is used as an agent for preventing or treating zoster- associated pain in acute phase : wherein R1 is hydrogen, a C1-8 alkyl group, or the like; each of R2 and R3 is hydrogen, a C1-8 alkyl group, or the like; each of R4 and R5 is hydrogen or the like; and W is a five-membered or six-membered heterocyclic ring optionally having one or more substituents and comprising one to four nitrogen atoms as the members of the ring.