专利名称 | AMIDE COMPOUND HAVING BET PROTEOLYSIS-INDUCING ACTION AND MEDICINAL APPLICATION THEREOF | ||
申请号 | WOJP19026553 | 申请日 | |
公开(公告)号 | WO2020009176A1 | 公开(公告)日 | |
申请(专利权)人 | MITSUBISHI TANABE PHARMA CORPORATION; KABUSHIKI KAISHA YAKULT HONSHA | 发明人 | YAMAZAKI Ryuta; IBUKI Tatsuya; SAWAGUCHI Yuichi; OHBA Kiyomi; HAMADA Maiko; NIWA Yasuki; ISHIDA Yuko; MARUYAMA Hideto; MATSUKI Shiki; TANAKA Minoru |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The present invention aims to provide a compound that : has an excellent cytotoxic action on cancer cells, excellent induction of BET protein degradation in cancer cells, and an excellent binding-inhibiting action on BET protein and acetylated histone; and is effective as an anti-cancer agent, a BET protein degradation-inducing agent, or a BET protein inhibiting agent. A compound indicated in general formula (I) or a pharmacologically acceptable salt thereof. {In the formula, each symbol is as outlined in the Description.} |