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专利概况
专利名称 AMIDE COMPOUND HAVING BET PROTEOLYSIS-INDUCING ACTION AND MEDICINAL APPLICATION THEREOF
申请号 WOJP19026553 申请日
公开(公告)号 WO2020009176A1 公开(公告)日
申请(专利权)人 MITSUBISHI TANABE PHARMA CORPORATION; KABUSHIKI KAISHA YAKULT HONSHA 发明人 YAMAZAKI Ryuta; IBUKI Tatsuya; SAWAGUCHI Yuichi; OHBA Kiyomi; HAMADA Maiko; NIWA Yasuki; ISHIDA Yuko; MARUYAMA Hideto; MATSUKI Shiki; TANAKA Minoru
专利来源 国家知识产权局 转化方式
摘要

The present invention aims to provide a compound that : has an excellent cytotoxic action on cancer cells, excellent induction of BET protein degradation in cancer cells, and an excellent binding-inhibiting action on BET protein and acetylated histone; and is effective as an anti-cancer agent, a BET protein degradation-inducing agent, or a BET protein inhibiting agent. A compound indicated in general formula (I) or a pharmacologically acceptable salt thereof. {In the formula, each symbol is as outlined in the Description.}

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