The invention belongs to the field of biological medicine, in particular refers to an alhydrogel - sodium chloride compound immunologic adjuvant, preparation method and use thereof. The technical problem to be solved by the invention is to provide a well-behaved and novel immunologic adjuvant. The technical solution for solving the technical problem of the invention is to provide the use of sodium chloride in the preparation of immunologic adjuvant and the alhydrogel - sodium chloride compound immunologic adjuvant obtained on the basis thereof. The compound immunologic adjuvant mainly comprises alhydrogel and sodium chloride. The alhydrogel - sodium chloride compound immunologic adjuvant of the invention is an excellent compound immunologic adjuvant, which can be used for various antigens, and provides a new and effective choice for the development and application of vaccines due to the advantages of simple and convenient use, low cost, strong immune activity, high clinical safety and the like.