专利名称 | IMMEDIATE-RELEASE ABUSE DETERRENT COMPOSITIONS OR MEDICAMENTS FOR TREATING PAIN, ADD, ADHD AND OTHER SYNDROMES OR DISORDERS | ||
申请号 | US16341636 | 申请日 | |
公开(公告)号 | US20200038383A1 | 公开(公告)日 | |
申请(专利权)人 | KEMPHARM INC | 发明人 | Travis Mickle; Sven M Geunther; Bindu Bera; Christopher Lauderback; Jessica Sims; Corinna Wetzel |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The presently described technology provides one or more compositions, preferably one or more immediate-release profile compositions, comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4, 5-alpha-epoxy-3-methoxy-17-methyl), or chemically conjugated to hydromorphone (4, 5, α-epoxy-3-hydroxy-17-methyl morphinan-6-one), in combination with at least one gel forming polymer; at least one disintegrant; and at least one surfactant to form novel compositions which have a decreased potential for abuse. The hydrocodone conjugate can also be combined with an analgesic, such as acetaminophen, to form a combinatorial composition that includes at least one gel forming polymer; at least one disintegrant; and at least one surfactant. The present technology also provides pharmaceutical kits and methods of synthesizing conjugates of the present technology. |