The present invention relates to a composition for inhibiting osteoclast differentiation comprising a gold preparation as an active ingredient, and, inhibitors for inhibiting osteoclast differentiation, inhibiting the expression of NFATc1 and interrupting phosphorylation of IKK-I κ Bα, blocking NF- κ B secretion of a, inflammation modulator complex, and improving bone density in IL-1β follicle-expressing animals models . and a method for inhibiting osteoclast differentiation by blocking, secretion of osteoclasts. , Is expected to be used in a variety of fields, for example, a composition for a, way material for medical, drugs and, food additives for use. in medicines for the prevention, or treatment of metabolic bone diseases caused by differentiation and differentiation of osteoclasts.