Disclosed are a traditional Chinese medicine composition that can protect the liver and promote bile secretion, and the preparation and use thereof. The effective ingredient raw materials of the traditional Chinese medicine composition comprise : Polygoni cuspidati rhizoma et radix, Citri reticulatae pericarpium viride, Crataegi fructus and rhubarb. The traditional Chinese medicine composition and an extract thereof can significantly reduce serum ALT, AST, ALP, T-Bil, D-Bil and TBA, significantly reduce hepatocyte necrosis, ameliorate hepatocyte swelling, cytoplasm rarefaction, ballooning degeneration and feathering degeneration, and reduce inflammatory cell infiltration, thereby preventing or treating cholestasis.