专利名称 | TOPICAL TETRACYCLINE COMPOSITIONS | ||
申请号 | US16578252 | 申请日 | |
公开(公告)号 | US20200016271A1 | 公开(公告)日 | |
申请(专利权)人 | Foamix Pharmaceuticals Ltd | 发明人 | Dov Tamarkin; Elana Gazal; Irakliy Papiashvili; Yohan Hazot; David Schuz; Rita Keynan |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force. |