专利名称 | BICYCLIC HETEROCYCLIC COMPOUNDS AS PDE2 INHIBITORS | ||
申请号 | EP16818525 | 申请日 | |
公开(公告)号 | EP3319966B1 | 公开(公告)日 | |
申请(专利权)人 | Merck Sharp Dohme Corp | 发明人 | STACHEL Shawn J; SINZ Christopher J; CHEN Yili; WILSON Jonathan E; DWYER Michael P; PAONE Daniel V; XU Shimin |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The present invention is directed to dihydropyrazolopyrimidinone compounds of formulas (I) and (II) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson' s disease, Parkinson' s disease dementia (PDD), or Huntington' s disease, and those associated with striatal hypofunction or basal ganglia dysfunction. |