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专利概况
专利名称 BICYCLIC HETEROCYCLIC COMPOUNDS AS PDE2 INHIBITORS
申请号 EP16818525 申请日
公开(公告)号 EP3319966B1 公开(公告)日
申请(专利权)人 Merck Sharp Dohme Corp 发明人 STACHEL Shawn J; SINZ Christopher J; CHEN Yili; WILSON Jonathan E; DWYER Michael P; PAONE Daniel V; XU Shimin
专利来源 国家知识产权局 转化方式
摘要

The present invention is directed to dihydropyrazolopyrimidinone compounds of formulas (I) and (II) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson' s disease, Parkinson' s disease dementia (PDD), or Huntington' s disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

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