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专利概况
专利名称 METHOD FOR TREATMENT OF PATIENTS WITH LARGE INTESTINE CANCER OR LUNG CANCER
申请号 RU2015147555 申请日
公开(公告)号 RU2713555C2 公开(公告)日
申请(专利权)人 ДЗЕ БОРД ОФ РИДЖЕНТС ОФ ДЗЕ ЮНИВЕРСИТИ ОФ ТЕХАС СИСТЕМ; DZE BORD OF RIDZHENTS OF DZE YUNIVERSITI OF TEKHAS SISTEM 发明人 ШЕЙ Джерри У; ШЕЙ Джерри У SHEJ Dzherri U; ГРЯЗНОВ Сергей М; ГРЯЗНОВ Сергей М GRYAZNOV Sergej M
专利来源 国家知识产权局 转化方式
摘要

FIELD : medicine; biochemistry.SUBSTANCE : method is proposed for treating a patient with large intestine cancer or lung cancer, where cancer cells express telomerase and are characterized by excessive activation of telomerase. In the method, a patient is administered a first pharmaceutical composition in an effective amount containing 6-thio-2' -deoxyguanosine and a second pharmaceutical composition in an effective amount containing a telomerase inhibitor, imetelstat sodium. Further, the total amount of the first and second compositions is more effective for reducing the stability of the length of the telomere and inducing the death of cells expressing telomerase than the amount of the first pharmaceutical composition separately or the amount of the second pharmaceutical composition separately.EFFECT : invention makes it possible to stabilize the length of telomeres for 12–16 weeks and does not allow cells to reverse the effect that the drug has on the length of telomeres for at least 2–4 weeks.8 cl, 8 dwg, 2 tbl, 1 ex

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