A hepatoprotective traditional Chinese medicine composition, an extract thereof, and a pharmaceutical use thereof. The composition comprises : root of Morinda officinalis, Lucid ganoderma, root of membranous milkvetch, catclaw buttercup root, root of lightyellow sophora, and root of ligulilobe sage. The composition and the extract thereof can be used for preventing liver damage, hepatitis, liver fibrosis, cirrhosis, and liver cancer, and can also be used as a vaccine adjuvant or an immunomodulator.